Article
Using in-cell SHAPE-Seq and simulations to probe structure-function design principles of RNA transcriptional regulators.
RNA (New York, N.Y.) - 1 Jun 2016
Takahashi Melissa K, Watters Kyle E, Gasper Paul M, Abbott Timothy R, Carlson Paul D, Chen Alan A, Lucks Julius B
Abstract excerpt
Antisense RNA-mediated transcriptional regulators are powerful tools for controlling gene expression and creating synthetic gene networks. RNA transcriptional repressors derived from natural mechanisms called attenuators are particularly versatile, though their mechanistic complexity has made them difficult to engineer. Here we identify a new structure-function design principle for attenuators that enables the...
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