Article
Leukotriene pathway polymorphisms are associated with altered cysteinyl leukotriene production in children with acute asthma.
Prostaglandins, leukotrienes, and essential fatty acids - 1 Jul 2009
Bizzintino Joelene A, Khoo Siew-Kim, Zhang Guicheng, Martin Andrew C, Rueter Kristina, Geelhoed Gary C, Goldblatt Jack, Laing Ingrid A, Le Souëf Peter N, Hayden Catherine M
Abstract excerpt
Cysteinyl leukotrienes (cysLTs) are pro-inflammatory mediators with increasing evidence for a role in childhood acute asthma. This study examined the influence of polymorphisms in cysLT pathway genes on urinary leukotriene E(4) (uLTE(4)) levels and clinical status in acute asthmatic children. Children aged 2-16 years were recruited during an asthma attack (n=205). Where possible, asthma severity scores were...
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