Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ALOX5 polymorphism associates with increased leukotriene production and reduced lung function and asthma control in children with poorly controlled asthma.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 May 2013

Mougey E, Lang J E, Allayee H, Teague W G, Dozor A J, Wise R A, Lima J J

Abstract excerpt

BACKGROUND: Identification of risk factors for reduced asthma control could improve the understanding and treatment of asthma. A promoter polymorphism in the 5-lipoxygenase gene affects gene expression and response to asthma therapy, but its impact on disease control remains unclear. OBJECTIVE: W...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arachidonate 5-Lipoxygenase
Share to Asthma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Binding Sites

Share to Gene Frequency

Share to Leukotrienes

Share to Promoter Regions, Genetic

Share to Respiratory Function Tests

Share to Sp1 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 23600541
DOI: 10.1111/cea.12076
PMCID: PMC3633142

Genes

ALOX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23600541-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ALOX5 polymorphism associates with increased leukotriene production and reduced lung function and asthma control in children with poorly controlled asthma.PMID 23600541Read ↗

ALOX5 promoter genotype, asthma severity and LTC production by eosinophils.Semantic proximity Read ↗

Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population.Semantic proximity Read ↗

Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association StudiesSemantic proximity Read ↗

Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment.Semantic proximity Read ↗

Functional variants of the human 5-lipoxygenase gene and their genetic diagnosis.Semantic proximity Read ↗

Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukastSemantic proximity Read ↗

Polymorphism of tandem repeat in promoter of 5‐lipoxygenase in ASA‐intolerant asthma: a positive association with airway hyperresponsivenessSemantic proximity Read ↗

The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers.Semantic proximity Read ↗

Leukotriene pathway polymorphisms are associated with altered cysteinyl leukotriene production in children with acute asthma.Semantic proximity Read ↗

The role of LTA4H and ALOX5AP polymorphism in asthma and allergy susceptibility.Semantic proximity Read ↗

Association of the -1072G/A polymorphism in the LTC4S gene with asthma in an Indian population.Semantic proximity Read ↗

The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.