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Article

Potentiation of ribonuclease cytotoxicity by a poly(amidoamine) dendrimer.

Bioorganic & medicinal chemistry letters - 1 May 2011

Ellis Gregory A, Hornung Megan L, Raines Ronald T

Abstract excerpt

Variants of bovine pancreatic ribonuclease (RNase A) engineered to evade the endogenous ribonuclease inhibitor protein (RI) are toxic to human cancer cells. Increasing the basicity of these variants facilitates their entry into the cytosol and thus increases their cytotoxicity. The installation of additional positive charge also has the deleterious consequence of decreasing ribonucleolytic activity or...

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Identifiers

PMID: 21144746
DOI: 10.1016/j.bmcl.2010.11.028
PMCID: PMC3081967

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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