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Article

A nuclear localization sequence endows human pancreatic ribonuclease with cytotoxic activity.

Biochemistry - 2 Mar 2004

Bosch Montserrat, Benito Antoni, Ribó Marc, Puig Teresa, Beaumelle Bruno, Vilanova Maria

Abstract excerpt

Some members of the ribonuclease superfamily, such as Onconase, are cytotoxic to cancer cells. This is not the case for human pancreatic ribonuclease. This lack of cytotoxicity is probably a result of the inhibition exerted by the cytosolic ribonuclease inhibitor once the protein has reached the cytosol. Until now, all cytotoxic human pancreatic ribonuclease variants have been described as being resistant to the...

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Identifiers

PMID: 14979713
DOI: 10.1021/bi035729+

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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