Article
The impact of CYP2D6 genetic polymorphisms on postoperative morphine consumption.
Pain medicine (Malden, Mass.) - 1 Jan 2000
Candiotti Keith A, Yang Zongqi, Rodriguez Yiliam, Crescimone Andres, Sanchez Greys C, Takacs Peter, Medina Carlos, Zhang Yanping, Liu Huanliang, Gitlin Melvin C
Abstract excerpt
BACKGROUND: Endogenous morphine-like compounds have been identified in humans and are released in response to stress. Human monocytes and granulocytes express the micro opiate receptor, micro3, which is morphine selective but opiate peptide insensitive. Recent studies have shown that CYP2D6 acts at critical steps for endogenous morphine biosynthesis. We theorized that ultrarapid (UM) CYP2D6 metabolizers may have...
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