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Article

Impact of the CYP2D6 genotype on post-operative intravenous oxycodone analgesia.

Acta anaesthesiologica Scandinavica - 1 Feb 2010

Zwisler S T, Enggaard T P, Mikkelsen S, Brosen K, Sindrup S H

Abstract excerpt

BACKGROUND: Oxycodone is a semi-synthetic opioid with a mu-receptor agonist-mediated effect in several pain conditions, including post-operative pain. Oxycodone is metabolized to its active metabolite oxymorphone by O-demethylation via the polymorphic CYP2D6. The aim of this study was to investigate whether CYP2D6 poor metabolizers (PMs) yield the same analgesia post-operatively from intravenous oxycodone as...

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Share to Analgesics, Opioid
Share to Cytochrome P-450 CYP2D6
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19719813
DOI: 10.1111/j.1399-6576.2009.02104.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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