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Article

Interaction of nalidixic acid and ciprofloxacin with wild type and mutated quinolone-resistance-determining region of DNA gyrase A.

Indian journal of biochemistry & biophysics - 1 Apr 2009

Vashist Jitendra, Vishvanath, Kapoor Renuka, Kapil Arti, Yennamalli Ragothaman, Subbarao N, Rajeswari Moganty R

Abstract excerpt

The quinolones exert their anti-bacterial activity by binding to DNA gyrase A (GyrA), an essential enzyme in maintenance of DNA topology within bacterial cell. The mutations conferring resistance to quinolones arise within the quinolone-resistance-determining region (QRDR) of GyrA. Therefore, quinolones interaction with wild and mutated GyrA can provide the molecular explanation for resistance. Resistant strains...

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PMID: 19517991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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