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Article

Exploration of fluoroquinolone resistance in Streptococcus pyogenes: comparative structure analysis of wild-type and mutant DNA gyrase.

Journal of molecular recognition : JMR - 1 Jun 2013

Shafreen Raja Mohmed Beema, Selvaraj Chandrabose, Singh Sanjeev Kumar, Pandian Shunmugiah Karutha

Abstract excerpt

Quinolone resistance-determining region is known to be the druggability site of the target protein that undergoes frequent mutation and thus renders quinolone resistance. In the present study, ligands were tested for their inhibitory activity against DNA gyrase of Streptococcus pyogenes involved in DNA replication. In silico mutational analysis on modelled gyrase A revealed that GLU85 had the most possible...

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PMID: 23595809
DOI: 10.1002/jmr.2270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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