Article
Specific patterns of gyrA mutations determine the resistance difference to ciprofloxacin and levofloxacin in Klebsiella pneumoniae and Escherichia coli.
BMC infectious diseases - 7 Jan 2013
Fu Yingmei, Zhang Wenli, Wang Hong, Zhao Song, Chen Yang, Meng Fanfei, Zhang Ying, Xu Hui, Chen Xiaobei, Zhang Fengmin
Abstract excerpt
BACKGROUND: Wide use of ciprofloxacin and levofloxacin has often led to increased resistance. The resistance rate to these two agents varies in different clinical isolates of Enterobacteriaceae. Mutations of GyrA within the quinolone resistance-determining regions have been found to be the main mechanism for quinolone resistance in Enterobacteriaceae. It has been shown that only some of the mutations in the gyrA...
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