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Article

Structure based in silico analysis of quinolone resistance in clinical isolates of Salmonella Typhi from India.

PloS one - 1 Jan 2015

Kumar Manoj, Dahiya Sushila, Sharma Priyanka, Sharma Sujata, Singh Tej P, Kapil Arti, Kaur Punit

Abstract excerpt

Enteric fever is a major cause of morbidity in several parts of the Indian subcontinent. The treatment for typhoid fever majorly includes the fluoroquinolone group of antibiotics. Excessive and indiscriminate use of these antibiotics has led to development of acquired resistance in the causative organism Salmonella Typhi. The resistance towards fluoroquinolones is associated with mutations in the target gene of...

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PMID: 25962113
DOI: 10.1371/journal.pone.0126560
PMCID: PMC4427296

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