Article
Amino Acid Substitution Ser83Ile in GyrA of DNA Gyrases Confers High-Level Quinolone Resistance to Nontyphoidal Salmonella Without Loss of Supercoiling Activity.
Microbial drug resistance (Larchmont, N.Y.) - 1 Oct 2021
Koide Kentaro, San Lai Lai, Pachanon Ruttana, Park Jong-Hoon, Ouchi Yuki, Kongsoi Siriporn, Utrarachkij Fuangfa, Nakajima Chie, Suzuki Yasuhiko
Abstract excerpt
Aims: Quinolone-resistant nontyphoidal Salmonella having serine replaced by isoleucine at the 83rd amino acid in GyrA (GyrA-Ser83Ile) has recently been found in Asian countries. In this study, we aimed to examine the direct effect of substitution Ser83Ile on DNA gyrase activity and/or resistance to quinolones. Materials and Methods: Using 50% of the maximal inhibitory concentrations (IC50s) of quinolones,...
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