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Article

Analytical profiling of mutations in quinolone resistance determining region of gyrA gene among UPEC.

PloS one - 1 Jan 2018

Varughese Lesley R, Rajpoot Meenakshi, Goyal Soniya, Mehra Ravinder, Chhokar Vinod, Beniwal Vikas

Abstract excerpt

Mutations in gyrA are the primary cause of quinolone resistance encountered in gram-negative clinical isolates. The prospect of this work was to analyze the role of gyrA mutations in eliciting high quinolone resistance in uropathogenic E.coli (UPEC) through molecular docking studies. Quinolone susceptibility testing of 18 E.coli strains isolated from UTI patients revealed unusually high resistance level to all...

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Share to DNA Gyrase
Share to Drug Resistance, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Escherichia coli Infections

Share to Molecular Docking Simulation

Share to Quinolones

Share to Sequence Homology, Nucleic Acid

Share to Urinary Tract Infections

Share to Uropathogenic Escherichia coli

Source

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Identifiers

PMID: 29300775
DOI: 10.1371/journal.pone.0190729
PMCID: PMC5754135

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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