The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of Māori and Pacific ancestry.

doi:10.1007/s00125-021-05552-x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of Māori and Pacific ancestry.

Diabetologia - 1 Dec 2021

Burden Hannah J, Adams Shannon, Kulatea Braydon, Wright-McNaughton Morag, Sword Danielle, Ormsbee Jennifer J, Watene-O'Sullivan Conor, Merriman Tony R, Knopp Jennifer L, Chase J Geoffrey, Krebs Jeremy D, Hall Rosemary M, Plank Lindsay D, Murphy Rinki, Shepherd Peter R, Merry Troy L

Abstract excerpt

AIMS/HYPOTHESIS: The minor A allele of rs373863828 (CREBRF p.Arg457Gln) is associated with increased BMI, but reduced risk of type 2 and gestational diabetes in Polynesian (Pacific peoples and Aotearoa New Zealand Māori) populations. This study investigates the effect of the A allele on insulin release and sensitivity in overweight/obese men without diabetes. METHODS: A mixed meal tolerance test was completed by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipokines, Inflammation, and Metabolic Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alleles

Share to Blood Glucose

Share to Diabetes Mellitus, Type 2

Share to Genetic Associations and Epidemiology

Share to Insulin

Share to Regulation of Appetite and Obesity

Share to Tumor Suppressor Proteins

Source

Open in PubMed

Identifiers

PMID: 34417843
DOI: 10.1007/s00125-021-05552-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of Māori and Pacific ancestry.PMID 34417843Read ↗

The Pacific-specific CREBRF rs373863828 allele protects against gestational diabetes mellitus in Māori and Pacific women with obesity.Semantic proximity Read ↗

Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand.Semantic proximity Read ↗

Discordant association of the <i>CREBRF</i> rs373863828 minor allele with increased body mass index and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa New ZealandSemantic proximity Read ↗

<i>CREBRF</i> missense variant rs373863828 has both direct and indirect effects on type 2 diabetes and fasting glucose in Polynesians living in Samoa and Aotearoa New ZealandSemantic proximity Read ↗

Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response.Semantic proximity Read ↗

The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body compositionSemantic proximity Read ↗

G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans.Semantic proximity Read ↗

Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects.Semantic proximity Read ↗

The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load.Semantic proximity Read ↗

Impact of PTBP1 rs11085226 on glucose-stimulated insulin release in adult Danes.Semantic proximity Read ↗

The missense variant, rs373863828, in CREBRF plays a role in longitudinal changes in body mass index in Samoans.Semantic proximity Read ↗

Evaluation of fasting state-/oral glucose tolerance test-derived measures of insulin release for the detection of genetically impaired β-cell function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.