Article
The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load.
BMC medical genetics - 6 Jan 2011
Hornbak Malene, Banasik Karina, Justesen Johanne M, Krarup Nikolaj T, Sandholt Camilla H, Andersson Åsa, Sandbæk Annelli, Lauritzen Torsten, Pisinger Charlotta, Witte Daniel R, Sørensen Thorkild A A, Pedersen Oluf, Hansen Torben
Abstract excerpt
BACKGROUND: A genome-wide association study (GWAS) using metabolite concentrations as proxies for enzymatic activity, suggested that two variants: rs2014355 in the gene encoding short-chain acyl-coenzyme A dehydrogenase (ACADS) and rs11161510 in the gene encoding medium-chain acyl-coenzyme A dehydrogenase (ACADM) impair fatty acid β-oxidation. Chronic exposure to fatty acids due to an impaired β-oxidation may...
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