Article
The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes.
Diabetes - 1 Feb 2003
Nielsen Eva-Maria D, Hansen Lars, Carstensen Bendix, Echwald Søren M, Drivsholm Thomas, Glümer Charlotte, Thorsteinsson Birger, Borch-Johnsen Knut, Hansen Torben, Pedersen Oluf
Abstract excerpt
The E23K polymorphism of the pancreatic beta-cell ATP-sensitive K(+) (K(ATP)) channel subunit Kir6.2 (KCNJ11) is associated with type 2 diabetes in whites, and a recent in vitro study of the E23K variant suggests that the association to diabetes might be explained by a slight inhibition of serum insulin release. In a study comprising 519 unrelated glucose-tolerant subjects, we addressed the question as to whether...
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