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Article

The Caenorhabditis elegans snf-11 gene encodes a sodium-dependent GABA transporter required for clearance of synaptic GABA.

Molecular biology of the cell - 1 Jul 2006

Mullen Gregory P, Mathews Eleanor A, Saxena Paurush, Fields Stephen D, McManus John R, Moulder Gary, Barstead Robert J, Quick Michael W, Rand James B

Abstract excerpt

Sodium-dependent neurotransmitter transporters participate in the clearance and/or recycling of neurotransmitters from synaptic clefts. The snf-11 gene in Caenorhabditis elegans encodes a protein of high similarity to mammalian GABA transporters (GATs). We show here that snf-11 encodes a functional GABA transporter; SNF-11-mediated GABA transport is Na+ and Cl- dependent, has an EC50 value of 168 microM, and is...

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Identifiers

PMID: 16641366
DOI: 10.1091/mbc.e06-02-0155
PMCID: PMC1483038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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