Article
SLO-1 potassium channels control quantal content of neurotransmitter release at the C. elegans neuromuscular junction.
Neuron - 6 Dec 2001
Wang Z W, Saifee O, Nonet M L, Salkoff L
Abstract excerpt
Six mutants of SLO-1, a large-conductance, Ca(2+)-activated K(+) channel of C. elegans, were obtained in a genetic screen for regulators of neurotransmitter release. Mutants were isolated by their ability to suppress lethargy of an unc-64 syntaxin mutant that restricts neurotransmitter release. We measured evoked postsynaptic currents at the neuromuscular junction in both wild-type and mutants and observed that...
Topics
- Amino Acid Sequence
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Excitatory Postsynaptic Potentials
- Large-Conductance Calcium-Activated Potassium Channels
- Molecular Sequence Data
- Mutation
- Neuromuscular Junction
- Neurotransmitter Agents
- Potassium Channels
- Potassium Channels, Calcium-Activated
- Presynaptic Terminals
- Xenopus