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Article

Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunit.

The EMBO journal - 7 Feb 2007

Scott John W, Ross Fiona A, Liu J K David, Hardie D Grahame

Abstract excerpt

The AMP-activated protein kinase (AMPK) system monitors cellular energy status by sensing AMP and ATP, and is a key regulator of energy balance at the cellular and whole-body levels. AMPK exists as heterotrimeric alphabetagamma complexes, and the gamma subunits contain two tandem domains that bind the regulatory nucleotides. There is a sequence in the first of these domains that is conserved in gamma subunit...

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Identifiers

PMID: 17255938
DOI: 10.1038/sj.emboj.7601542
PMCID: PMC1794397

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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