Article
Regional differences in cerebral perfusion associated with the alpha-2A-adrenergic receptor genotypes in attention deficit hyperactivity disorder.
Journal of psychiatry & neuroscience : JPN - 1 Sept 2010
Kim Boong-Nyun, Kim Jae-Won, Kang Hyejin, Cho Soo-Churl, Shin Min-Sup, Yoo Hee-Jeong, Hong Soon-Beom, Lee Dong Soo
Abstract excerpt
BACKGROUND: Neurobiologic studies have suggested that dysregulation of central noradrenergic systems may be involved in the pathophysiology of attention deficit hyperactivity disorder (ADHD), and it has been hypothesized that genetic changes in the norepinephrine pathways might contribute to dysfunction of the prefrontal cortex circuits in ADHD. We previously reported decreased cerebral blood flow in the right...
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