Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults.

doi:10.1007/s00429-014-0895-5

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Article

Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults.

Brain structure & function - 1 Jan 2016

Meyer Bernhard M, Huemer Julia, Rabl Ulrich, Boubela Roland N, Kalcher Klaudius, Berger Andreas, Banaschewski Tobias, Barker Gareth, Bokde Arun, Büchel Christian, Conrod Patricia, Desrivières Sylvane, Flor Herta, Frouin Vincent, Gallinat Jurgen, Garavan Hugh, Heinz Andreas, Ittermann Bernd, Jia Tianye, Lathrop Mark, Martinot Jean-Luc, Nees Frauke, Rietschel Marcella, Smolka Michael N, Bartova Lucie, Popovic Ana, Scharinger Christian, Sitte Harald H, Steiner Hans, Friedrich Max H, Kasper Siegfried, Perkmann Thomas, Praschak-Rieder Nicole, Haslacher Helmuth, Esterbauer Harald, Moser Ewald, Schumann Gunter, Pezawas Lukas

Abstract excerpt

Prefrontal dopamine levels are relatively increased in adolescence compared to adulthood. Genetic variation of COMT (COMT Val158Met) results in lower enzymatic activity and higher dopamine availability in Met carriers. Given the dramatic changes of synaptic dopamine during adolescence, it has been suggested that effects of COMT Val158Met genotypes might have oppositional effects in adolescents and adults. The...

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PMID: 25319752
DOI: 10.1007/s00429-014-0895-5
PMCID: PMC4667398

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COMT

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