Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intra-tumor heterogeneity of MLH1 promoter methylation revealed by deep single molecule bisulfite sequencing.

Nucleic acids research - 1 Aug 2009

Varley Katherine E, Mutch David G, Edmonston Tina B, Goodfellow Paul J, Mitra Robi D

Abstract excerpt

A single tumor may contain cells with different somatic mutations. By characterizing this genetic heterogeneity within tumors, advances have been made in the prognosis, treatment and understanding of tumorigenesis. In contrast, the extent of epigenetic intra-tumor heterogeneity and how it influences tumor biology is under-explored. We have characterized epigenetic heterogeneity within individual tumors using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endometrial Neoplasms

Share to Endometrium

Share to Epigenesis, Genetic

Share to MutL Protein Homolog 1

Share to Nuclear Proteins

Share to Sulfites

Source

Open in PubMed Open full text

Identifiers

PMID: 19494183
DOI: 10.1093/nar/gkp457
PMCID: PMC2724279

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intra-tumor heterogeneity of MLH1 promoter methylation revealed by deep single molecule bisulfite sequencing.PMID 19494183Read ↗

DNA methylation variability defines a fundamental dimension of tumor epigenomes linked to genomic instability, tumor aggressiveness, and clinical outcomesSemantic proximity Read ↗

SINEultaneous profiling of epigenetic heterogeneity and transcriptome in single cellsSemantic proximity Read ↗

Linking transcriptional and genetic tumor heterogeneity through allele analysis of single-cell RNA-seq data.Semantic proximity Read ↗

Intratumor heterogeneity in epigenetic patternsSemantic proximity Read ↗

Substantial genomic and methylation variability between MCF-7 sublinesSemantic proximity Read ↗

Intratumoral heterogeneity in microsatellite instability at single cell resolutionSemantic proximity Read ↗

DNA methylation variability defines a fundamental dimension of tumor epigenomes linked to genomic instability, tumor aggressiveness, and clinical outcomesSemantic proximity Read ↗

Increased methylation variation in epigenetic domains across cancer types.Semantic proximity Read ↗

Frequent hypermethylation of MLH1 promoter in normal endometrium of patients with endometrial cancers.Semantic proximity Read ↗

Microsatellite Instability–High Endometrial Cancers with MLH1 Promoter Hypermethylation Have Distinct Molecular and Clinical ProfilesSemantic proximity Read ↗

Depleted-MLH1 Expression Predicts Prognosis and Immunotherapeutic Efficacy in Uterine Corpus Endometrial Cancer: An In Silico ApproachSemantic proximity Read ↗

Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.