Article

Substantial genomic and methylation variability between MCF-7 sublines

2026-02-19

Abstract excerpt

Cancer cell lines have long been used as in vitro models for molecular assays in diagnostic and therapeutic development due to their accessibility as a well-controlled system. MCF-7 cell lines are the most widely studied cell lines in human breast cancer research, and its sublines have been reported to exhibit clonal, cytogenetic, and transcriptomic variability. However, allele-specific methylation alterations in...

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Literature Corpus work: d5e931f7-380b-55db-9179-616d473a6dbe
DOI: 10.64898/2026.02.17.706500

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