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Article

Different mechanisms of hepatitis C virus RNA polymerase activation by cyclophilin A and B in vitro.

Biochimica et biophysica acta - 1 Dec 2012

Weng Leiyun, Tian Xiao, Gao Yayi, Watashi Koichi, Shimotohno Kunitada, Wakita Takaji, Kohara Michinori, Toyoda Tetsuya

Abstract excerpt

BACKGROUND: Cyclophilins (CyPs) are cellular proteins that are essential to hepatitis C virus (HCV) replication. Since cyclosporine A was discovered to inhibit HCV infection, the CyP pathway contributing to HCV replication is a potential attractive stratagem for controlling HCV infection. Among them, CyPA is accepted to interact with HCV nonstructural protein (NS) 5A, although interaction of CyPB and NS5B, an...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22954804
DOI: 10.1016/j.bbagen.2012.08.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Different mechanisms of hepatitis C virus RNA polymerase activation by cyclophilin A and B in vitro.PMID 22954804Read ↗

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Cyclophilin A Is an Essential Cofactor for Hepatitis C Virus Infection and the Principal Mediator of Cyclosporine Resistance In VitroSemantic proximity Read ↗

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