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Locating the stem cell niche and tracing hepatocyte lineages in human liver #

23 Dec 2008

Abstract excerpt

UNLABELLED: We have used immunohistochemical and histochemical techniques to identify patches of hepatocytes deficient in the enzyme cytochrome c oxidase, a component of the electron transport chain and encoded by mitochondrial DNA (mtDNA). These patches invariably abutted the portal tracts and expanded laterally as they spread toward the hepatic veins. Here we investigate, using mtDNA mutations as a marker of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19309719
DOI: 10.1002/hep.22791

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