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Article

<i>In situ</i> lineage tracking of human prostatic epithelial stem cell fate reveals a common clonal origin for basal and luminal cells

15 Jul 2011

Abstract excerpt

Stem cells accumulate mitochondrial DNA (mtDNA) mutations resulting in an observable respiratory chain defect in their progeny, allowing the mapping of stem cell fate. There is considerable uncertainty in prostate epithelial biology where both basal and luminal stem cells have been described, and in this study the clonal relationships within the human prostate epithelial cell layers were explored by tracing stem...

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PMID: 21898876
DOI: 10.1002/path.2965

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