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Article

The HIV-1 latent reservoir is largely sensitive to circulating T cells.

eLife - 6 Oct 2020

Warren Joanna A, Zhou Shuntai, Xu Yinyan, Moeser Matthew J, MacMillan Daniel R, Council Olivia, Kirchherr Jennifer, Sung Julia M, Roan Nadia R, Adimora Adaora A, Joseph Sarah, Kuruc JoAnn D, Gay Cynthia L, Margolis David M, Archin Nancie, Brumme Zabrina L, Swanstrom Ronald, Goonetilleke Nilu

Abstract excerpt

HIV-1-specific CD8+ T cells are an important component of HIV-1 curative strategies. Viral variants in the HIV-1 reservoir may limit the capacity of T cells to detect and clear virus-infected cells. We investigated the patterns of T cell escape variants in the replication-competent reservoir of 25 persons living with HIV-1 (PLWH) durably suppressed on antiretroviral therapy (ART). We identified all reactive T...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33021198
DOI: 10.7554/eLife.57246
PMCID: PMC7593086

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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