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Article

Parkin promotes intracellular Abeta1-42 clearance.

Human molecular genetics - 1 Sept 2009

Burns Mark P, Zhang Lihua, Rebeck G William, Querfurth Henry W, Moussa Charbel E-H

Abstract excerpt

Alzheimer's disease and Parkinson's disease are common neurodegenerative diseases that may share some underlying mechanisms of pathogenesis. Abeta(1-42) fragments are found intracellularly, and extracellularly as amyloid plaques, in Alzheimer's disease and in dementia with Lewy Bodies. Parkin is an E3-ubiquitin ligase involved in proteasomal degradation of intracellular proteins. Mutations in parkin, which result...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19483198
DOI: 10.1093/hmg/ddp258
PMCID: PMC2733820

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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