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Article

Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 Feb 2007

Henn Iris H, Bouman Lena, Schlehe Julia S, Schlierf Anita, Schramm Julia E, Wegener Elmar, Nakaso Kazuhiro, Culmsee Carsten, Berninger Benedikt, Krappmann Daniel, Tatzelt Jörg, Winklhofer Konstanze F

Abstract excerpt

Mutations in the parkin gene are a major cause of autosomal recessive Parkinson's disease. Here we show that the E3 ubiquitin ligase parkin activates signaling through the IkappaB kinase (IKK)/nuclear factor kappaB (NF-kappaB) pathway. Our analysis revealed that activation of this signaling cascade is causally linked to the neuroprotective potential of parkin. Inhibition of NF-kappaB activation by an IkappaB...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17314283
DOI: 10.1523/JNEUROSCI.5537-06.2007
PMCID: PMC6673568

Genes

TNF
TRAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling.PMID 17314283Read ↗

Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling.Semantic proximity Read ↗

Parkin negatively regulates the antiviral signaling pathway by targeting TRAF3 for degradationSemantic proximity Read ↗

Elevated TRAF2/6 expression in Parkinson's disease is caused by the loss of Parkin E3 ligase activity.Semantic proximity Read ↗

Parkin: a multifaceted ubiquitin ligaseSemantic proximity Read ↗

Parkin: much more than a simple ubiquitin ligase.Semantic proximity Read ↗

Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways.Semantic proximity Read ↗

Therapeutic potential of Parkin and its regulation in Parkinson's disease.Semantic proximity Read ↗

Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1.Semantic proximity Read ↗

Parkin ubiquitinates and promotes the degradation of RanBP2.Semantic proximity Read ↗

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity.Semantic proximity Read ↗

Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6.Semantic proximity Read ↗

Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.Semantic proximity Read ↗

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