Article
Proteasome inhibition promotes Parkin-Ubc13 interaction and lysine 63-linked ubiquitination.
PloS one - 1 Jan 2013
Lim Grace G Y, Chew Katherine C M, Ng Xiao-Hui, Henry-Basil Adeline, Sim Roy W X, Tan Jeanne M M, Chai Chou, Lim Kah-Leong
Abstract excerpt
Disruption of the ubiquitin-proteasome system, which normally identifies and degrades unwanted intracellular proteins, is thought to underlie neurodegeneration. Supporting this, mutations of Parkin, a ubiquitin ligase, are associated with autosomal recessive parkinsonism. Remarkably, Parkin can protect neurons against a wide spectrum of stress, including those that promote proteasome dysfunction. Although the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.