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Article

Decreased parkin solubility is associated with impairment of autophagy in the nigrostriatum of sporadic Parkinson's disease.

Neuroscience - 1 Mar 2013

Lonskaya I, Hebron M L, Algarzae N K, Desforges N, Moussa C E-H

Abstract excerpt

Parkinson's disease (PD) is a motor disorder that involves death of dopaminergic neurons in the substantia nigra pars compacta. Parkin is an autosomal recessive gene that is mutated in early onset PD. We investigated the role of parkin and autophagic clearance in postmortem nigrostriatal tissues from 22 non-familial sporadic PD patients and 15 control samples. Parkin was insoluble with altered cytosolic...

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Identifiers

PMID: 23262240
DOI: 10.1016/j.neuroscience.2012.12.018
PMCID: PMC3618990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Decreased parkin solubility is associated with impairment of autophagy in the nigrostriatum of sporadic Parkinson's disease.PMID 23262240Read ↗

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Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.Semantic proximity Read ↗

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