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Article

Decreased parkin solubility is associated with impairment of autophagy in the nigrostriatum of sporadic Parkinson's disease.

Neuroscience - 1 Mar 2013

Lonskaya I, Hebron M L, Algarzae N K, Desforges N, Moussa C E-H

Abstract excerpt

Parkinson's disease (PD) is a motor disorder that involves death of dopaminergic neurons in the substantia nigra pars compacta. Parkin is an autosomal recessive gene that is mutated in early onset PD. We investigated the role of parkin and autophagic clearance in postmortem nigrostriatal tissues...

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Identifiers

PMID: 23262240
DOI: 10.1016/j.neuroscience.2012.12.018
PMCID: PMC3618990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23262240-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Decreased parkin solubility is associated with impairment of autophagy in the nigrostriatum of sporadic Parkinson's disease.PMID 23262240Read ↗

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Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.Semantic proximity Read ↗

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