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Article

The effects of parkin suppression on the behaviour, amyloid processing, and cell survival in APP mutant transgenic mice.

Experimental neurology - 1 Jan 2010

Perucho Juan, Casarejos Maria J, Rubio Isabel, Rodriguez-Navarro José A, Gómez Ana, Ampuero Israel, Rodal Izaskun, Solano Rosa M, Carro Eva, García de Yébenes Justo, Mena Maria A

Abstract excerpt

Parkin suppression induces accumulation of beta-amyloid in mutant tau mice. We studied the effect of parkin suppression on behaviour and brain pathology in APP(swe) mutant mice. We produced double mutant mice with human mutated APP(swe)+partial (hemizygote) or total (homozygote) deletion of Park-2 gene. We studied the development, behaviour, brain histology, and biochemistry of 12- and 16-month-old animals in 6...

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Source

Identifiers

PMID: 19815012
DOI: 10.1016/j.expneurol.2009.09.029

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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