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Article

The first propeller domain of LRP6 regulates sensitivity to DKK1.

Molecular biology of the cell - 1 Aug 2009

Binnerts Minke E, Tomasevic Nenad, Bright Jessica M, Leung John, Ahn Victoria E, Kim Kyung-Ah, Zhan Xiaoming, Liu Shouchun, Yonkovich Shirlee, Williams Jason, Zhou Mei, Gros Delphine, Dixon Melissa, Korver Wouter, Weis William I, Abo Arie

Abstract excerpt

The Wnt coreceptor LRP6 is required for canonical Wnt signaling. To understand the molecular regulation of LRP6 function, we generated a series of monoclonal antibodies against the extra cellular domain (ECD) of LRP6 and selected a high-affinity mAb (mAb135) that recognizes cell surface expression of endogenous LRP6. mAb135 enhanced Wnt dependent TCF reporter activation and antagonized DKK1 dependent inhibition...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intercellular Signaling Peptides and Proteins

Share to LDL-Receptor Related Proteins

Share to Low Density Lipoprotein Receptor-Related Protein-6

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Source

Open in PubMed Open full text

Identifiers

PMID: 19477926
DOI: 10.1091/mbc.e08-12-1252
PMCID: PMC2719573

Genes

LRP6
DKK1
ECD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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