Article
Conformational Freedom of the LRP6 Ectodomain Is Regulated by N-glycosylation and the Binding of the Wnt Antagonist Dkk1.
Cell reports - 3 Jan 2017
Matoba Kyoko, Mihara Emiko, Tamura-Kawakami Keiko, Miyazaki Naoyuki, Maeda Shintaro, Hirai Hidenori, Thompson Samuel, Iwasaki Kenji, Takagi Junichi
Abstract excerpt
LDL-receptor-related protein 6 (LRP6) is a single-pass membrane glycoprotein with a large modular ectodomain and forms a higher order signaling platform upon binding Wnt ligands on the cell surface. Although multiple crystal structures are available for fragments of the LRP6 ectodomain, we lack a consensus view on the overall molecular architecture of the full-length LRP6 and its dynamic aspects. Here, we used...
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