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Article

Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance.

Circulation research - 21 Nov 2008

Liu Wenzhong, Mani Sheida, Davis Nicole R, Sarrafzadegan Nizal, Kavathas Paula B, Mani Arya

Abstract excerpt

Mutation in the EGFP domain of LDL receptor-related protein 6 (LRP6(R611C)) is associated with hypercholesterolemia and early-onset atherosclerosis, but the mechanism by which it causes disease is not known. Cholesterol uptake was examined in cells from LRP6(+/-) mice and LRP6(R611C) mutation car...

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Source

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Identifiers

PMID: 18948618
DOI: 10.1161/CIRCRESAHA.108.183863
PMCID: PMC3426315

Genes

LRP6
NPC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18948618-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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