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Article

A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor.

Molecular and cellular biology - 1 Aug 2003

Liu Guizhong, Bafico Anna, Harris Violaine K, Aaronson Stuart A

Abstract excerpt

LDL receptor-related protein 6 (LRP6) is a Wnt coreceptor in the canonical signaling pathway, which plays essential roles in embryonic development. We demonstrate here that wild-type LRP6 forms an inactive dimer through interactions mediated by epidermal growth factor repeat regions within the ex...

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Identifiers

PMID: 12897152
DOI: 10.1128/MCB.23.16.5825-5835.2003
PMCID: PMC166321

Genes

LRP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12897152-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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