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Article

Coordinated control of replication and transcription by a SAPK protects genomic integrity.

Nature - 3 Jan 2013

Duch Alba, Felipe-Abrio Irene, Barroso Sonia, Yaakov Gilad, García-Rubio María, Aguilera Andrés, de Nadal Eulàlia, Posas Francesc

Abstract excerpt

Upon environmental changes or extracellular signals, cells are subjected to marked changes in gene expression. Dealing with high levels of transcription during replication is critical to prevent collisions between the transcription and replication pathways and avoid recombination events. In response to osmostress, hundreds of stress-responsive genes are rapidly induced by the stress-activated protein kinase...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23178807
DOI: 10.1038/nature11675

Genes

MRC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Coordinated control of replication and transcription by a SAPK protects genomic integrity.PMID 23178807Read ↗

The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress.Semantic proximity Read ↗

Hog1 activation delays mitotic exit via phosphorylation of Net1.Semantic proximity Read ↗

Recruitment of a chromatin remodelling complex by the Hog1 MAP kinase to stress genes.Semantic proximity Read ↗

Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1.Semantic proximity Read ↗

The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes.Semantic proximity Read ↗

Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase.Semantic proximity Read ↗

Stress-induced nuclear accumulation is dispensable for Hog1-dependent gene expression and virulence in a fungal pathogen.Semantic proximity Read ↗

The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway-dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage.Semantic proximity Read ↗

S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex.Semantic proximity Read ↗

Structure and function of a transcriptional network activated by the MAPK Hog1.Semantic proximity Read ↗

Surprising regulatory plasticity for the conserved HOG pathway in diverse <i>Saccharomyces cerevisiae</i> strainsSemantic proximity Read ↗

Mrc1 is required for normal progression of replication forks throughout chromatin in S. cerevisiae.Semantic proximity Read ↗

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