Article
Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase.
EMBO reports - 30 Sept 2011
Vendrell Alexandre, Martínez-Pastor Mar, González-Novo Alberto, Pascual-Ahuir Amparo, Sinclair David A, Proft Markus, Posas Francesc
Abstract excerpt
Exposure of yeast to high osmolarity induces a transient activation of the Hog1 stress-activated protein kinase (SAPK), which is required for cell survival under these conditions. However, sustained activation of the SAPK results in a severe growth defect. We found that prolonged SAPK activation leads to cell death, which is not observed in nma111 cells, by causing accumulation of reactive oxygen species (ROS)....
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