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Article

Mitogen-activated protein kinase Hog1 mediates adaptation to G1 checkpoint arrest during arsenite and hyperosmotic stress.

Eukaryotic cell - 1 Aug 2008

Migdal Iwona, Ilina Yulia, Tamás Markus J, Wysocki Robert

Abstract excerpt

Cells slow down cell cycle progression in order to adapt to unfavorable stress conditions. Yeast (Saccharomyces cerevisiae) responds to osmotic stress by triggering G(1) and G(2) checkpoint delays that are dependent on the mitogen-activated protein kinase (MAPK) Hog1. The high-osmolarity glycerol (HOG) pathway is also activated by arsenite, and the hog1Delta mutant is highly sensitive to arsenite, partly due to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18552285
DOI: 10.1128/EC.00038-08
PMCID: PMC2519783

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mitogen-activated protein kinase Hog1 mediates adaptation to G1 checkpoint arrest during arsenite and hyperosmotic stress.PMID 18552285Read ↗

Mitogen-activated protein kinase Hog1 is essential for the response to arsenite in Saccharomyces cerevisiae.Semantic proximity Read ↗

Hog1 activation delays mitotic exit via phosphorylation of Net1.Semantic proximity Read ↗

The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress.Semantic proximity Read ↗

Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1.Semantic proximity Read ↗

Evidence of a new role for the high-osmolarity glycerol mitogen-activated protein kinase pathway in yeast: regulating adaptation to citric acid stress.Semantic proximity Read ↗

The MAPK Hog1p modulates Fps1p-dependent arsenite uptake and tolerance in yeast.Semantic proximity Read ↗

Activation of the Hog1 MAPK by the Ssk2/Ssk22 MAP3Ks, in the absence of the osmosensors, is not sufficient to trigger osmostress adaptation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Analysis of mitogen-activated protein kinase signaling specificity in response to hyperosmotic stress: use of an analog-sensitive HOG1 allele.Semantic proximity Read ↗

Vacuolar H+-ATPase works in parallel with the HOG pathway to adapt Saccharomyces cerevisiae cells to osmotic stress.Semantic proximity Read ↗

Sphingolipids regulate the yeast high-osmolarity glycerol response pathway.Semantic proximity Read ↗

Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase.Semantic proximity Read ↗

Unique and redundant roles for HOG MAPK pathway components as revealed by whole-genome expression analysis.Semantic proximity Read ↗

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