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Article

Lamprey VLRB response to influenza virus supports universal rules of immunogenicity and antigenicity

7 Aug 2015

Abstract excerpt

Immunoglobulins (Igs) are a crown jewel of jawed vertebrate evolution. Through recombination and mutation of small numbers of genes, Igs can specifically recognize a vast variety of natural and man-made organic molecules. Jawless vertebrates evolved a parallel system of humoral immunity, which recognizes antigens not with Ig, but with a structurally unrelated receptor called the variable lymphocyte receptor B...

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PMID: 26252514
DOI: 10.7554/elife.07467

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