Article
Diversity and function of adaptive immune receptors in a jawless vertebrate.
Science (New York, N.Y.) - 23 Dec 2005
Alder Matthew N, Rogozin Igor B, Iyer Lakshminarayan M, Glazko Galina V, Cooper Max D, Pancer Zeev
Abstract excerpt
Instead of the immunoglobulin-type antigen receptors of jawed vertebrates, jawless fish have variable lymphocyte receptors (VLRs), which consist of leucine-rich repeat (LRR) modules. Somatic diversification of the VLR gene is shown here to occur through a multistep assembly of LRR modules randomly selected from a large bank of flanking cassettes. The predicted concave surface of the VLR is lined with...
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