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Article

Structural insight into the autoinhibition mechanism of AMP-activated protein kinase.

Nature - 25 Jun 2009

Chen Lei, Jiao Zhi-Hao, Zheng Li-Sha, Zhang Yuan-Yuan, Xie Shu-Tao, Wang Zhi-Xin, Wu Jia-Wei

Abstract excerpt

The AMP-activated protein kinase (AMPK) is characterized by its ability to bind to AMP, which enables it to adjust enzymatic activity by sensing the cellular energy status and maintain the balance between ATP production and consumption in eukaryotic cells. It also has important roles in the regulation of cell growth and proliferation, and in the establishment and maintenance of cell polarity. These important...

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PMID: 19474788
DOI: 10.1038/nature08075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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