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Article

The dynamical mechanism of auto-inhibition of AMP-activated protein kinase.

PLoS computational biology - 1 Jul 2011

Peng Cheng, Head-Gordon Teresa

Abstract excerpt

We use a novel normal mode analysis of an elastic network model drawn from configurations generated during microsecond all-atom molecular dynamics simulations to analyze the mechanism of auto-inhibition of AMP-activated protein kinase (AMPK). A recent X-ray and mutagenesis experiment (Chen, et al Nature 2009, 459, 1146) of the AMPK homolog S. Pombe sucrose non-fermenting 1 (SNF1) has proposed a new conformational...

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Identifiers

PMID: 21814500
DOI: 10.1371/journal.pcbi.1002082
PMCID: PMC3140967

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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