E-cadherin genetic screening and clinico-pathologic characteristics of early onset gastric cancer.

doi:10.1016/j.ejca.2010.10.011

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Article

E-cadherin genetic screening and clinico-pathologic characteristics of early onset gastric cancer.

European journal of cancer (Oxford, England : 1990) - 1 Mar 2011

Corso Giovanni, Pedrazzani Corrado, Pinheiro Hugo, Fernandes Eduardo, Marrelli Daniele, Rinnovati Andrea, Pascale Valeria, Seruca Raquel, Oliveira Carla, Roviello Franco

Abstract excerpt

AIM: CDH1 germline alterations occur in about 40% of hereditary diffuse gastric cancer (HDGC) families. CDH1 germline mutations are also documented in few early onset diffuse gastric cancer patients (EODGC) without family history, but the real frequency in this setting in unknown. In these patients, the advanced stage at the time of diagnosis remains a clinical burden due to the poor long term survival. METHODS:...

Topics

Adult
Antigens, CD
Cadherins
Cell Adhesion
DNA Methylation
Early Detection of Cancer
Female
Genetic Predisposition to Disease
Genetic Testing
Germ-Line Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Loss of Heterozygosity

Male

Middle Aged

Mutation, Missense

Neoplasm Invasiveness

Stomach Neoplasms

Source

Open in PubMed

Identifiers

PMID: 21106365
DOI: 10.1016/j.ejca.2010.10.011

Genes

CDH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21106365-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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