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The Assessment of Interleukin-18 on the Risk of Coronary Heart Disease

4 Oct 2019

Abstract excerpt

BACKGROUND: Observational studies support the inflammation hypothesis in coronary heart disease (CHD). As a pleiotropic proinflammatory cytokine, Interleukin-18 (IL-18), has also been found to be associated with the risk of CHD. However, to our knowledge, the method of Mendelian Randomization has not been used to explore the causal effect of IL-18 on CHD. OBJECTIVE: To assess the causal effect of IL-18 on the...

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PMID: 31584380
DOI: 10.2174/1573406415666191004115128

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