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Article

Calcilytic Ameliorates Abnormalities of Mutant Calcium-Sensing Receptor (CaSR) Knock-In Mice Mimicking Autosomal Dominant Hypocalcemia (ADH).

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2015

Dong Bingzi, Endo Itsuro, Ohnishi Yukiyo, Kondo Takeshi, Hasegawa Tomoka, Amizuka Norio, Kiyonari Hiroshi, Shioi Go, Abe Masahiro, Fukumoto Seiji, Matsumoto Toshio

Abstract excerpt

Activating mutations of calcium-sensing receptor (CaSR) cause autosomal dominant hypocalcemia (ADH). ADH patients develop hypocalcemia, hyperphosphatemia, and hypercalciuria, similar to the clinical features of hypoparathyroidism. The current treatment of ADH is similar to the other forms of hypoparathyroidism, using active vitamin D3 or parathyroid hormone (PTH). However, these treatments aggravate...

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PMID: 25967373
DOI: 10.1002/jbmr.2551

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PTH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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