Article

Differential activation of parathyroid and renal Ca <sup>2+</sup> -sensing receptors underlies the renal phenotype in autosomal dominant hypocalcemia 1

2021-02-02

Abstract excerpt

<h4>Background</h4> Parathyroid Ca 2+ -sensing receptor (CaSR) activation inhibits parathyroid hormone (PTH) release, while activation of CaSRs in kidneys and intestine attenuates local transepithelial Ca 2+ transport. In patients with autosomal dominant hypocalcemia 1 (ADH1) due to activating CASR mutations, treatment of symptomatic hypocalcemia can be complicated by treatment-induced hypercalciuria, resultin...

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Literature Corpus work: 09c4d8e0-18de-5b6c-a34f-340da185c249
DOI: 10.1101/2021.02.01.429170

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