Split-dose exposure to N-methyl-N'-nitro-N-nitrosoguanidine in BALB/3T3 C1 a31-1-1 cells: evidence of DNA repair by alkaline elution without changes in cell survival, mutation and transformation rates.

doi:10.1016/0167-8817(85)90044-6

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Article

Split-dose exposure to N-methyl-N'-nitro-N-nitrosoguanidine in BALB/3T3 C1 a31-1-1 cells: evidence of DNA repair by alkaline elution without changes in cell survival, mutation and transformation rates.

Mutation research - 1 Jan 2000

Bignami M, Dogliotti E, Benigni R, Kaighn M E, Saffiotti U

Abstract excerpt

Dose fractionation of a direct-acting chemical carcinogen, the alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), was studied for its concurrent effects on survival, DNA damage and repair, ouabain resistance (Ouar) mutations and neoplastic transformation, in the mouse embryo cell line...

Topics

Animals
Cell Survival
Cell Transformation, Neoplastic
Cells, Cultured
DNA Repair
Methylnitronitrosoguanidine
Mice
Mutation
X-Rays

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