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Article

Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderly.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jul 2009

Kölsch Heike, Wagner Michael, Bilkei-Gorzó Andras, Toliat Mohammad Reza, Pentzek Michael, Fuchs Angela, Kaduszkiewicz Hanna, van den Bussche Hendrik, Riedel-Heller Steffi G, Angermeyer Matthias C, Weyerer Siegfried, Werle Jochen, Bickel Horst, Mösch Edelgard, Wiese Birgitt, Daerr Moritz, Jessen Frank, Maier Wolfgang, Dichgans Martin

Abstract excerpt

Cognitive functions show large variation in elderly people and are substantially heritable. Animal studies revealed that dynorphins influence cognition and memory, especially in aged animals. Thus, we tested the effect of four SNPs (rs7272891, rs1997794, rs2235751 and rs910080) and the VNTR promoter polymorphism in the prodynorphin gene (PDYN) on episodic memory and verbal fluency in a large (n = 1619) sample of...

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Source

Identifiers

PMID: 19468819
DOI: 10.1007/s00702-009-0238-5

Genes

PDYN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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