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Article

The linker region of Smad2 mediates TGF-beta-dependent ERK2-induced collagen synthesis.

Biochemical and biophysical research communications - 21 Aug 2009

Li Fengfeng, Zeng Bingfang, Chai Yimin, Cai Peihua, Fan Cunyi, Cheng Tao

Abstract excerpt

Transforming growth factor (TGF)-beta1 can cause fibrosis diseases by enhancing production of collagen. However, the intracellular signaling mechanism for TGF-beta1 stimulation of this process has not been fully elucidated. The present study focused on this mechanism and the cross-talk between the MAPK and Smad pathways. Extracellular signal-regulated kinase (ERK)2 ablation by a small interfering RNA led to...

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Identifiers

PMID: 19465000
DOI: 10.1016/j.bbrc.2009.05.084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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